| ncRNA name | Dnmt1 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Bos taurus |
| Tissues/Cell_line | bovine retinal endothelial cells |
| Methods | siRNA transfection, MS-PCR, qPCR, cell apoptosis |
| Expression pattern | associated |
| Functional description | High glucose increased mtDNA methylation, and methylation was significantly higher at the D-loop than at the Cytb and CoxII regions. Mitochondrial accumulation of Dnmt1 and its binding at the D-loop were also significantly increased. Inhibition of Dnmt by its siRNA or pharmacologic inhibitor ameliorated glucose-induced increase in 5mC levels and cell apoptosis. |
| PubMed ID | 26241401 |
| Year | 2015 |
| Title | Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy. |
| Drug-related ncRNA | NO |
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